Structure of PDB 7lhz Chain C

Receptor sequence
>7lhzC (length=714) Species: 507522 (Klebsiella pneumoniae 342) [Search protein sequence]
GKLADCTAQDLNRTELFLVEGDSAGGSAKQARDREYQAIMPLKGKILNTW
EVSSDEVLASQEVHDISVAIGIDPDSDDLSQLRYGKICILADADSDGLHI
ATLLCALFVRHFRTLVKEGHVYVALPPLYRIDLGKEVYYALTEEEKTGVL
EQLKRKKGKPNVQRFKGLGEMNPMQLRETTLDPNTRRLVQLVISDEDEQQ
TTAIMDMLLAKKRSEDRRNWLQEKGDMADLMSDMAERLALHEFTENAYLN
YSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNASAKFKKSARTVGDV
LGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRY
TESRLSKYAELLLSELGQGTVDWVPNFDGTLQEPKMLPARLPNILLNGTT
GIAVGMATDIPPHNLREVAKAAITLIEQPKTTLDELLDIVQGPDFPTEAE
IITSRAEIRKIYQNGRGSVRMRAVWSKEDGAVVITALPHQVSGAKVLEQI
AAQMRNKKLPMVDDLRDESDHENPTRLVIVPRSNRVDMEQVMNHLFATTD
LEKSYRINLNMIGLDGRPAVKNLLEILSEWLVFRRDTVRRRLNHRLEKVL
KRLHILEGLLVAFLNIDEVIEIIRTEDEPKPALMSRFGISETQAEAILEL
KLRHLAKLEEMKIRGEQSELEKERDQLQAILASERKMNNLLKKELQADAD
AFGDDRRSPLHERE
3D structure
PDB7lhz Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria.
ChainC
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7lhz, PDBe:7lhz, PDBj:7lhz
PDBsum7lhz
PubMed33929852
UniProtB5XU53;
B5XU60

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