Structure of PDB 7lg8 Chain C

Receptor sequence
>7lg8C (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
LLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATS
PKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYV
REHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVK
ITDFGLAKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDG
IPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELIIE
FSKMARDPQRYLVIQGFYRALMDE
3D structure
PDB7lg8 Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors.
ChainC
Resolution2.93 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VNS C V726 A743 I744 K745 I759 M766 L777 L788 M790 D855 F856 L858 K860 V24 A41 I42 K43 I57 M64 L75 L86 M88 D153 F154 L156 K158
BS02 8RC C L718 G719 A743 M790 Q791 L792 M793 P794 F795 G796 C797 D800 E804 M1002 L16 G17 A41 M88 Q89 L90 M91 P92 F93 G94 C95 D98 E102 M272
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7lg8, PDBe:7lg8, PDBj:7lg8
PDBsum7lg8
PubMed35534503
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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