Structure of PDB 7lc1 Chain C

Receptor sequence
>7lc1C (length=167) Species: 9606 (Homo sapiens) [Search protein sequence]
GMTEYKLVVVGAGGVGKSALTIQLIANHFVDEYDPTIEDSYRKQVVIDGE
TCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQ
IKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTR
QGVDDAFYTLVREIRKH
3D structure
PDB7lc1 RAS interaction with Sin1 is dispensable for mTORC2 assembly and activity.
ChainC
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG C S17 T35 S18 T36
BS02 GNP C G13 V14 G15 K16 S17 A18 V29 D30 Y32 P34 T35 G60 N116 K117 D119 S145 A146 K147 G14 V15 G16 K17 S18 A19 V30 D31 Y33 P35 T36 G61 N117 K118 D120 S146 A147 K148
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:7lc1, PDBe:7lc1, PDBj:7lc1
PDBsum7lc1
PubMed34380736
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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