Structure of PDB 7l2x Chain C

Receptor sequence
>7l2xC (length=536) Species: 10116 (Rattus norvegicus) [Search protein sequence]
SYTDSYYKGQTALHIAIERRNMTLVTLLVENGADVQAAANGDFFKKTKGR
PGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALV
EVADNTVDNTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAAS
SGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEK
NSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIFYFNFFVYC
LYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSGGVYFFFRG
IQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVASMV
FSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFS
TAVVTLIEDGKYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFIILLLA
YVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKC
MRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTT
3D structure
PDB7l2x Structural snapshots of TRPV1 reveal mechanism of polymodal functionality.
ChainC
Resolution3.26 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6IY C K656 A657 K441 A442
BS02 6IY C M581 Y584 M389 Y392
BS03 6EU C L515 M547 Y554 R557 L323 M355 Y362 R365 BindingDB: Ki=0.13nM,IC50=180nM
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7l2x, PDBe:7l2x, PDBj:7l2x
PDBsum7l2x
PubMed34496225
UniProtO35433|TRPV1_RAT Transient receptor potential cation channel subfamily V member 1 (Gene Name=Trpv1)

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