Structure of PDB 7l24 Chain C

Receptor sequence
>7l24C (length=283) Species: 9606 (Homo sapiens) [Search protein sequence]
IFNRDPRDHYDLLQRLGGGTYGEVFKARDKVSGDLVALKMVKMEPDDDVS
TLQKEILILKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTG
SLSELQISYVCREVLQGLAYLHSQKKIHRDIKGANILINDAGEVRLADFG
ISAQIGAARRLAFITPYWMAPEVAAVALKGCYNELCDIWSLGITAIELAE
LQPPLFDVHPLRVLFLMTKSGYQPPRLKEKGKWSAAFHNFIKVTLTKSPK
KRPSATKMLSHQLVSQPGLNRGLILDLLDKLKN
3D structure
PDB7l24 Identification of Potent Reverse Indazole Inhibitors for HPK1.
ChainC
Resolution2.68 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D137 K139 A141 N142 D155 A164 T175
Catalytic site (residue number reindexed from 1) D130 K132 A134 N135 D148 A157 T165
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 XHV C A44 M91 E92 F93 C94 G95 G97 L144 D155 A37 M84 E85 F86 C87 G88 G90 L137 D148
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7l24, PDBe:7l24, PDBj:7l24
PDBsum7l24
PubMed33738073
UniProtQ92918|M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 (Gene Name=MAP4K1)

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