Structure of PDB 7kyh Chain C

Receptor sequence
>7kyhC (length=385) Species: 1491 (Clostridium botulinum) [Search protein sequence]
FVNKQFNYKDPVNGVDIAYIKIPNVMQPVKAFKIHNKIWVIPERDTFTNP
EEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLG
RMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVII
GPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEEAGKFAT
DPAVTLAHELIHAGHRLYGIAINPNVSFEELRTFGGHDAKFIDSLQENEF
RLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEKYLLSEDTSGKFS
VDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNFDKAVFKINIVPKV
NYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLK
3D structure
PDB7kyh Discovery of Dipeptides as Potent Botulinum Neurotoxin A Light-Chain Inhibitors.
ChainC
Resolution2.91 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.69: bontoxilysin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C H223 H227 E262 H208 H212 E230
BS02 XBM C P69 V70 F163 F194 H223 E224 H227 Y366 D370 P65 V66 F159 F190 H208 E209 H212 Y334 D338
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7kyh, PDBe:7kyh, PDBj:7kyh
PDBsum7kyh
PubMed33603978
UniProtP0DPI0|BXA1_CLOBO Botulinum neurotoxin type A (Gene Name=botA)

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