Structure of PDB 7kyf Chain C

Receptor sequence
>7kyfC (length=398) Species: 1491 (Clostridium botulinum) [Search protein sequence]
FVNKQFNYKDPVNGVDIAYIKIPNVMQPVKAFKIHNKIWVIPERDTFTNP
EEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLG
RMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVII
GPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEEAGKFAT
DPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNASGLEVSFEELRTFGGH
DAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKE
KYLLSEDTSGKFSVDKLKFDKLYKMLTEIYTEDNFVKFFKVLNRKTYLNF
DKAVFKINIVPKVNYTIYDGFNLRNTNLAANFNGQNTEINNMNFTKLK
3D structure
PDB7kyf Discovery of Dipeptides as Potent Botulinum Neurotoxin A Light-Chain Inhibitors.
ChainC
Resolution2.33 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.69: bontoxilysin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C H223 H227 E262 H208 H212 E243
BS02 XC1 C Q162 F163 T220 H223 E224 H227 E262 R363 Y366 F369 Q158 F159 T205 H208 E209 H212 E243 R344 Y347 F350
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:7kyf, PDBe:7kyf, PDBj:7kyf
PDBsum7kyf
PubMed33603978
UniProtP0DPI0|BXA1_CLOBO Botulinum neurotoxin type A (Gene Name=botA)

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