Structure of PDB 7knp Chain C

Receptor sequence

>7knpC (length=511) Species: 235443 (Cryptococcus neoformans var. grubii H99)

LFAPPPRMQGKEGRPKPHIGPNYESYVKEWAKTVGPNSDEWWAAKARETL
DWYDDFKTVRAGGFEHGDVQWFPEGTLNAAYNCLDRHYYKNPKKTAIIYE
ADEPSESREVSYEELMQETCRVANVLKSYGVKKGDAVSIYLPMTWQAAAA
FLACARIGAIHSAVFAGFSAESLRDRVNDCECKVLITTDEGRRGGKTIAT
KQIVDAALQQCPLVENVLVLRRTGNKVPMTEGRDKWWDEECAKMPAYCPC
ERMASEDPLFILYTSKPKGVVHSTAGYLLGTALTLKYVFDAHPDDRFACM
ADIGWITGHSYIIYGPLANGITTAVFESTPVYPTPSRYWDFVDKWKATQL
YTAPTAIRLLRRMGEDHVKNHDLSSLRVLGSVGEPINPEAWHWYNDFAGK
NQCAIVDTYWMTETGSISIAPLPGAISTKPGSATFPFFGMDVDIIDPQTG
QVLEGNDVEGVLVARRPWPSIARTVYRDHKRYLETYMKPYPGYFFFGDGA
ARDYDGYMWIK

3D structure

• PDB: 7knp Crystal structure of Acetyl-CoA synthetase in complex with adenosine-5'-butylphosphate from Cryptococcus neoformans var. grubii serotype A (H99)
• Chain: C
• Resolution: 2.25 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): T289 T441 E442
• Catalytic site (residue number reindexed from 1): T264 T412 E413
• Enzyme Commision number: 6.2.1.1: acetate--CoA ligase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	WT7	C	G412 P414 T437 Y438 W439 M440 T441 D527	G383 P385 T408 Y409 W410 M411 T412 D498

Gene Ontology

Molecular Function

• GO:0003987 acetate-CoA ligase activity
• GO:0005524 ATP binding
• GO:0016208 AMP binding
• GO:0016874 ligase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006085 acetyl-CoA biosynthetic process
• GO:0019427 acetyl-CoA biosynthetic process from acetate

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:7knp, PDBe:7knp, PDBj:7knp
• PDBsum: 7knp
• UniProt: J9VFT1