Structure of PDB 7kkn Chain C

Receptor sequence
>7kknC (length=207) Species: 9606 (Homo sapiens) [Search protein sequence]
GTILLDLAPEDKEYQSVEEEMQSTIREHRDGGNAGGIFNRYNVIRIQKVV
NKKLRERFCHRQKEVSEENHNHHNERMLFHGSPFINAIIHKGFDERHAYI
GGMFGAGIYFAENSSKSNQYVYGIGGGTGCPTHKDRSCYICHRQMLFCRV
TLGKSFLQFSTMKMAHAPPGHHSVIGRPSVLAYAEYVIYRGEQAYPEYLI
TYQIMKP
3D structure
PDB7kkn Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1.
ChainC
Resolution1.48 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C C1234 H1237 C1242 C1245 C130 H133 C138 C141
BS02 2YQ C H1184 G1185 Y1203 G1205 G1206 Y1213 F1214 A1215 K1220 S1221 Y1224 H80 G81 Y99 G101 G102 Y109 F110 A111 K116 S117 Y120
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:7kkn, PDBe:7kkn, PDBj:7kkn
PDBsum7kkn
PubMed33361107
UniProtO95271|TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=TNKS)

[Back to BioLiP]