Structure of PDB 7kjm Chain C

Receptor sequence
>7kjmC (length=84) Species: 9606 (Homo sapiens) [Search protein sequence]
TLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIV
YCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVV
3D structure
PDB7kjm CRYSTAL STRUCTURE OF HUMAN MDM2 IN COMPLEX WITH D-PEPTIDE INHIBITOR (DPMI-OMEGA)
ChainC
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C H96 R97 H71 R72
BS02 peptide C K51 L54 F55 G58 I61 Y67 Q72 H73 V93 K94 H96 I99 Y100 K26 L29 F30 G33 I36 Y42 Q47 H48 V68 K69 H71 I74 Y75
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:7kjm, PDBe:7kjm, PDBj:7kjm
PDBsum7kjm
PubMed
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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