Structure of PDB 7kiu Chain C

Receptor sequence
>7kiuC (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
PMRICSFNVRSFGESKQEDKNAMDVIVKVIKRCDIILVMEIKDSNNRICP
ILMEKLNRNSRRGITYNYVISSRLGRNTYKEQYAFLYKEKLVSVKRSYHY
HDYQDGDADVFSREPFVVWFQSPHTAVKDFVIIPLHTTPETSVKEIDELV
EVYTDVKHRWKAENFIFMGDFNAGCSYVPKKAWKNIRLRTDPRFVWLIGD
QEDTTVKKSTNCAYDRIVLRGQEIVSSVVPKSNSVFDFQKAYKLTEEEAL
DVSDHFPVEFKLQ
3D structure
PDB7kiu Structural features of Dnase1L3 responsible for serum antigen clearance.
ChainC
Resolution2.22 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.21.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG C D222 T224 K226 T229 D203 T205 K207 T210
BS02 MG C D189 H274 D170 H255
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0004530 deoxyribonuclease I activity
GO:0004536 DNA nuclease activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0002283 neutrophil activation involved in immune response
GO:0002673 regulation of acute inflammatory response
GO:0006259 DNA metabolic process
GO:0006308 DNA catabolic process
GO:0006309 apoptotic DNA fragmentation
GO:0006915 apoptotic process
GO:0010623 programmed cell death involved in cell development
GO:0070948 regulation of neutrophil mediated cytotoxicity
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7kiu, PDBe:7kiu, PDBj:7kiu
PDBsum7kiu
PubMed35974043
UniProtQ13609|DNSL3_HUMAN Deoxyribonuclease gamma (Gene Name=DNASE1L3)

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