Structure of PDB 7khs Chain C

Receptor sequence
>7khsC (length=427) Species: 314256 (Oceanicola granulosus HTCC2516) [Search protein sequence]
MLTGVIEGFYGRDWRRDERATVMDWIAAAGMNTYIYGPKDDVHVRARWRV
PYDAAGLARLTELRDAAAARGMVFYVSLAPCLDVTDRAALLARVDQLARA
GLRNLVLLFDDFAEAQADLSNMVLRHLRGAGHVVFCPTEYCGRMAGGDPR
GSAYLQRLGSTLDPAIDIFWTGPEIVSEEIVAAHLAAVGEVLRRRPVIWD
NFHANDYDIRRVFAGPLGGRSRDILPLVAGWITNPNNEAEANFPAIHTTG
AYLADPDYAPERAIAAAVAAWQPRFRLAFGDGAVPSDLVALLCDLFWQPF
ALGPETTRILSALRAALTVPRPDPSDPAWRAALEDLRDLKRRINKLFTLM
TEIENRDLFHTFHNYLWEAQEEVGHLVAYCDWLDEAPPPGAVFPATDRIH
NFYRRGFGVAVQDILQRDRQGRYHHGV
3D structure
PDB7khs Diazaspirononane Nonsaccharide Inhibitors of O-GlcNAcase (OGA) for the Treatment of Neurodegenerative Disorders.
ChainC
Resolution1.78 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.169: protein O-GlcNAcase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WG4 C G8 Y10 K39 Y160 W219 N221 D226 N254 G8 Y10 K39 Y140 W199 N201 D206 N234
BS02 WG4 C F367 H383 W387 F347 H363 W367
Gene Ontology
Molecular Function
GO:0015929 hexosaminidase activity
GO:0016231 beta-N-acetylglucosaminidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0102571 [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006517 protein deglycosylation
GO:1901135 carbohydrate derivative metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7khs, PDBe:7khs, PDBj:7khs
PDBsum7khs
PubMed33197187
UniProtQ2CEE3|OGA_OCEGH Protein O-GlcNAcase (Gene Name=OG2516_04129)

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