Structure of PDB 7kfz Chain C

Receptor sequence
>7kfzC (length=168) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAGDVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQI
KRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQ
GVDDAFYTLVREIRKHKE
3D structure
PDB7kfz Molecular assemblies of the catalytic domain of SOS with KRas and oncogenic mutants.
ChainC
Resolution3.47 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP C D13 G15 K16 S17 A18 F28 D30 Y32 T35 G60 K117 D119 L120 S145 A146 K147 D13 G15 K16 S17 A18 F28 D30 Y32 T35 G60 K117 D119 L120 S145 A146 K147
BS02 MG C S17 T35 S17 T35
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7kfz, PDBe:7kfz, PDBj:7kfz
PDBsum7kfz
PubMed33723061
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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