Structure of PDB 7kbh Chain C

Receptor sequence
>7kbhC (length=367) Species: 9606 (Homo sapiens) [Search protein sequence]
KKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPH
KATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLF
EFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIV
LAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYYFP
GTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSA
VVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIR
NVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTP
EYMEKIKQRLFENLRML
3D structure
PDB7kbh Discovery of Highly Selective and Potent HDAC3 Inhibitors Based on a 2-Substituted Benzamide Zinc Binding Group.
ChainC
Resolution2.68 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.-
3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C D177 H179 D266 D169 H171 D258
BS02 CA C F188 V194 Y224 F180 V186 Y216
BS03 CA C D175 D177 H179 F199 D167 D169 H171 F191
BS04 WB4 C H29 P30 M31 E99 D100 L140 G150 F151 H179 F207 D266 L273 G302 G303 H21 P22 M23 E91 D92 L132 G142 F143 H171 F199 D258 L265 G294 G295
Gene Ontology
Molecular Function
GO:0004407 histone deacetylase activity

View graph for
Molecular Function
External links
PDB RCSB:7kbh, PDBe:7kbh, PDBj:7kbh
PDBsum7kbh
PubMed33335670
UniProtQ92769|HDAC2_HUMAN Histone deacetylase 2 (Gene Name=HDAC2)

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