Structure of PDB 7k72 Chain C

Receptor sequence
>7k72C (length=318) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
TAPEVLRQWQALAEEVREHQFRYYVRDAPIISDAEFDELLRRLEALEEQH
PELRTPDSPTQLVGGAGFATDFEPVDHLERMLSLDNAFTADELAAWAGRI
HAEVGDAAHYLCELKIDGVALSLVYREGRLTRASTRGDGRTGEDVTLNAR
TIADVPERLTPGDDYPVPEVLEVRGEVFFRLDDFQALNASLVEEGKAPFA
NPRNSAAGSLRQKDPAVTARRRLRMICHGLGHVEGFRPATLHQAYLALRA
WGLPVSEHTTLATDLAGVRERIDYWGEHRHEVDHEIDGVVVKVDEVALQR
RLGSTSRAPRWAIAYKYP
3D structure
PDB7k72 Structure of DNA ligase A from Mycobacterium tuberculosis bound to NAD
ChainC
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.5.1.2: DNA ligase (NAD(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAD C H27 Y31 Y32 P37 I39 D41 F44 D45 S91 L92 E121 K123 I124 R144 E184 H236 K300 K324 H19 Y23 Y24 P29 I31 D33 F36 D37 S83 L84 E113 K115 I116 R136 E176 H228 K292 K316
BS02 MG C Y32 F44 Y24 F36
Gene Ontology
Molecular Function
GO:0003911 DNA ligase (NAD+) activity

View graph for
Molecular Function
External links
PDB RCSB:7k72, PDBe:7k72, PDBj:7k72
PDBsum7k72
PubMed
UniProtP9WNV1|DNLJ_MYCTU DNA ligase A (Gene Name=ligA)

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