Structure of PDB 7jxp Chain C

Receptor sequence
>7jxpC (length=292) Species: 9606 (Homo sapiens) [Search protein sequence]
NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELRE
ATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLL
DYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQ
HVKITDFGLAVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPY
DGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELI
IEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDM
3D structure
PDB7jxp Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
ChainC
Resolution2.16 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JBJ C F723 V726 A743 I744 K745 I759 E762 M766 R776 L777 L788 M790 D855 F856 L858 F24 V27 A44 I45 K46 I60 E63 M67 R77 L78 L89 M91 D156 F157 L159 BindingDB: IC50=>1000nM
BS02 YY3 C L718 G719 G721 V726 A743 L792 M793 G796 C797 D800 R841 L844 D855 L19 G20 G22 V27 A44 L93 M94 G97 C98 D101 R142 L145 D156 BindingDB: IC50=2.0nM,Ki=14nM,EC50=6.0nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7jxp, PDBe:7jxp, PDBj:7jxp
PDBsum7jxp
PubMed
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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