Structure of PDB 7jxk Chain C

Receptor sequence
>7jxkC (length=292) Species: 9606 (Homo sapiens) [Search protein sequence]
QALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREA
TSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLD
YVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQH
VKITDFGLAKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPY
DGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELI
IEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDM
3D structure
PDB7jxk Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
ChainC
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8BS C L718 G719 G721 V726 M790 M793 C797 D800 L844 L18 G19 G21 V26 M90 M93 C97 D100 L144
BS02 JBJ C A743 I744 K745 E758 I759 E762 M766 C775 R776 L777 L788 M790 D855 F856 L858 A43 I44 K45 E58 I59 E62 M66 C75 R76 L77 L88 M90 D155 F156 L158 BindingDB: IC50=>1000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7jxk, PDBe:7jxk, PDBj:7jxk
PDBsum7jxk
PubMed
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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