Structure of PDB 7jtn Chain C

Receptor sequence
>7jtnC (length=702) Species: 9606 (Homo sapiens) [Search protein sequence]
QGSCSLEGVEIKGGSFRLLQEGQALEYVCPSGFYPYPVQTRTCRSTGSWS
TLKTKTVRKAECRAIHCPRPHDFENGEYWPRSPYYNVSDEISFHCYDGYT
LRGSANRTCQVNGRWSGQTAICDNGAGYCSNPGIPIGTRKVGSQYRLEDS
VTYHCSRGLTLRGSQRRTCQEGGSWSGTEPSCQDSFMYDTPQEVAEAFLS
SLTETIKRKIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKVA
SYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEGTNTKK
ALQAVYSMMSWPDDVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRD
LLYIGKDRKNPREDYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKD
MENLEDVFYQMIDESQSLSLCGMVWEHRKGTDYHKQPWQAKISVIRPSKG
HESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVSVGGEKRDLEIEVVLFHP
NYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCTEGTTRAL
RLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCE
RDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHK
RSRFIQVGVISWGVVDVCKNQVPAHARDFHINLFQVLPWLKEKLQDEDLG
FL
3D structure
PDB7jtn Inhibition of the Complement Alternative Pathway by Chemically Modified DNA Aptamers That Bind with Picomolar Affinity to Factor B.
ChainC
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.47: alternative-complement-pathway C3/C5 convertase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna C E519 R521 K562 E487 R489 K530
BS02 rna C V46 T48 T50 R52 S53 S58 T59 K61 T62 R168 S196 L408 N410 V38 T40 T42 R44 S45 S50 T51 K53 T54 R157 S185 L376 N378
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006956 complement activation
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7jtn, PDBe:7jtn, PDBj:7jtn
PDBsum7jtn
PubMed33419768
UniProtP00751|CFAB_HUMAN Complement factor B (Gene Name=CFB)

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