Structure of PDB 7jga Chain C

Receptor sequence
>7jgaC (length=515) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence]
ADIEGAIEDYVSSFEEIGTVIDAGDGIAHVEGLPSVMTQELLEFPGGVLG
VALNLDEHSVGAVILGEFEKIEEGQQVKRTGEVLSVPVGDAFLGRVVNPL
GQPIDGQGDIAAETRRALELQAPSVVQRQSVSEPLQTGIKAIDAMTPIGR
GQRQLIIGDRKTGKTAVCVDTILNQREAWLTGDPKQQVRCVYVAIGQKGT
TIASVKRALEEGGAMEYTTIVAAPASDAAGFKWLAPYTGSAIGQHWMYNG
KHVLIVFDDLSKQADAYRAISLLLRRPPGREAFPGDVFYLHSRLLERCAK
LSDELGGGSMTGLPIIETKANDISAFIPTNVISITDGQCFLESDLFNQGV
RPAINVGVSVSRVGGAAQIKAMKEVAGSLRLDLSQYRELEAFAAFASDLD
AASKAQLDRGARLVELLKQPQYSPLAVEEQVVAIFLGTQGHLDSVPVEDV
QRFESELLEHVKASHSDIFDGIRETKKLSEEAEEKLVSVINEFKKGFQAS
DLEKESVKVRKPAPK
3D structure
PDB7jga Structure of mycobacterial ATP synthase bound to the tuberculosis drug bedaquiline.
ChainC
Resolution3.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K178 Q211 K212 R376
Catalytic site (residue number reindexed from 1) K164 Q197 K198 R362
Enzyme Commision number 7.1.2.2: H(+)-transporting two-sector ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP C K175 G177 K178 T179 A180 F360 R365 Q433 Q435 K161 G163 K164 T165 A166 F346 R351 Q419 Q421
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0032559 adenyl ribonucleotide binding
GO:0043531 ADP binding
GO:0046933 proton-transporting ATP synthase activity, rotational mechanism
GO:0046961 proton-transporting ATPase activity, rotational mechanism
Biological Process
GO:0006754 ATP biosynthetic process
GO:0015986 proton motive force-driven ATP synthesis
GO:0046034 ATP metabolic process
GO:1902600 proton transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0045259 proton-transporting ATP synthase complex
GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7jga, PDBe:7jga, PDBj:7jga
PDBsum7jga
PubMed33299175
UniProtA0R202|ATPA_MYCS2 ATP synthase subunit alpha (Gene Name=atpA)

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