Structure of PDB 7f8h Chain C

Receptor sequence
>7f8hC (length=262) Species: 9606 (Homo sapiens) [Search protein sequence]
AGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEM
IFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSADGFHSGVDW
MRKLAFRYRRVKEMYNTYKNNVGGLIGTPKRETWLQLRAELEALTDLWLT
HSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSAT
KTGKESCFERIMQRFGRKAVYVVIGDGVEEEQGAKKHNMPFWRISCHADL
EALRHALELEYL
3D structure
PDB7f8h Structure-activity relationship studies of allosteric inhibitors of EYA2 tyrosine phosphatase.
ChainC
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.48: protein-tyrosine-phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1SI C T278 I279 F282 Y294 T421 W424 L425 T17 I18 F21 Y33 T145 W148 L149
Gene Ontology
Molecular Function
GO:0004725 protein tyrosine phosphatase activity
Biological Process
GO:0007275 multicellular organism development

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Molecular Function
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Biological Process
External links
PDB RCSB:7f8h, PDBe:7f8h, PDBj:7f8h
PDBsum7f8h
PubMed34761455
UniProtO00167|EYA2_HUMAN Eyes absent homolog 2 (Gene Name=EYA2)

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