Structure of PDB 7f3p Chain C

Receptor sequence
>7f3pC (length=353) Species: 29323 (Thermoanaerobacter brockii) [Search protein sequence]
HMKGFAMLSIGKVGWIEKEKPAPGPFDAIVRPLAVAPCTSDIHTVFEGAI
GERHNMILGHEAVGEVVEVGSEVKDFKPGDRVVVSALTPDWRTSEVQRGY
HQHSGGMLAGWKFSNVKDGVFGEFFHVNDADMNLAHLPKEIPLEAAVMIP
DMMTTGFHGAELADIELGATVAVLGIGPVGLMAVAGAKLRGAGRIIAVGS
RPVCVDAAKYYGATDIVNYKDGPIESQIMNLTEGKGVDAAIIAGGNADIM
ATAVKIVKPGGTIANVNYFGEGEVLPVPRLEWGCGMAHKTIKGGLCPGGR
LRMERLIDLVFYKRVDPSKLVTHVFRGFDNIEKAFMLMKDKPKDLIKPVV
ILA
3D structure
PDB7f3p Unlocking the Stereoselectivity and Substrate Acceptance of Enzymes: Proline-Induced Loop Engineering Test.
ChainC
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.80: isopropanol dehydrogenase (NADP(+)).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP C S39 W110 D150 T154 G174 I175 G176 P177 V178 S199 R200 Y218 G244 N266 Y267 K340 S40 W111 D151 T155 G175 I176 G177 P178 V179 S200 R201 Y219 G245 N267 Y268 K341
BS02 ZN C C37 H59 D150 C38 H60 D151
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0050009 isopropanol dehydrogenase (NADP+) activity

View graph for
Molecular Function
External links
PDB RCSB:7f3p, PDBe:7f3p, PDBj:7f3p
PDBsum7f3p
PubMed34658118
UniProtP14941|ADH_THEBR NADP-dependent isopropanol dehydrogenase (Gene Name=adh)

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