Structure of PDB 7ewa Chain C

Receptor sequence
>7ewaC (length=152) Species: 9606 (Homo sapiens) [Search protein sequence]
GMTEYKLVVVGADGVGKSALTIQLIQNHEDSYRKQVVIDGETCLLDILDT
AGDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGN
KCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKH
KE
3D structure
PDB7ewa KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge.
ChainC
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP C G13 G15 K16 S17 A18 N116 K117 D119 S145 A146 K147 G14 G16 K17 S18 A19 N100 K101 D103 S129 A130 K131
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ewa, PDBe:7ewa, PDBj:7ewa
PDBsum7ewa
PubMed35075146
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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