Structure of PDB 7ekt Chain C

Receptor sequence
>7ektC (length=396) Species: 9606 (Homo sapiens) [Search protein sequence]
GEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVL
TTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERF
DATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWS
YGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTF
TVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSL
TVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDP
DGGKMPKWTRVILLNWCAWFLRMKRDLAKILEEVRYIANRFRCQDESEAV
CSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
3D structure
PDB7ekt Structural basis of human alpha 7 nicotinic acetylcholine receptor activation.
ChainC
Resolution3.02 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I33 C S56 L57 S58 W77 L78 Q79 L141 D186 S34 L35 S36 W55 L56 Q57 L119 D164 BindingDB: Ki=9.98nM,EC50=250nM
BS02 I34 C L235 N236 P240 F275 L213 N214 P218 F253 BindingDB: EC50=3800nM
BS03 CLR C W330 T331 L470 C471 A474 W308 T309 L364 C365 A368
BS04 I33 C W171 Y210 C212 Y217 W149 Y188 C190 Y195 BindingDB: Ki=9.98nM,EC50=250nM
BS05 I34 C M276 V290 A298 M254 V268 A276 BindingDB: EC50=3800nM
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
GO:0005216 monoatomic ion channel activity
GO:0005230 extracellular ligand-gated monoatomic ion channel activity
GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0034220 monoatomic ion transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0045211 postsynaptic membrane

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Cellular Component
External links
PDB RCSB:7ekt, PDBe:7ekt, PDBj:7ekt
PDBsum7ekt
PubMed33958730
UniProtP36544|ACHA7_HUMAN Neuronal acetylcholine receptor subunit alpha-7 (Gene Name=CHRNA7)

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