Structure of PDB 7ect Chain C

Receptor sequence

>7ectC (length=460) Species: 33178 (Aspergillus terreus)

MSNLPVEPEFEQAYKELASTLENSTLFQKNPEYRKALAVVSVPERVIQFR
VVWENDKGEVQVNRGFRVQFNSALGPYKGGLRFHPSVNLSILKFLGFEQI
FKNALTGLNMGGGKGGSDFDPKGKSDSEIRRFCVAFMTELCRHIGADTDV
PAGDIGVTGREIGYLFGQYRKLRNSWEGVLTGKGGSWGGSLIRPEATGYG
VVYYVEHMIAHATNGAESFAGKRVAISGSGNVAQYAALKVIELGGRVVSL
SDSQGSLIVKDTAKDSFTPAEIDAIAALKVDRKQIAELVTDAAFADKFTY
LPGQRPWVHVGAVDVALPSATQNEVSGEEAQALIAAGCKFIAEGSNMGCT
QAAIDAFEAHREANKGAAAIWYAPGKAANAGGVAVSGLEMAQNSARLSWT
AEEVDARLKDIMKSCFQNGLDTAKEYATPADGILPSLVTGSNIAGFTKVA
AAMKDQGDWW

3D structure

• PDB: 7ect Molecular insights into the inhibition of glutamate dehydrogenase by the dicarboxylic acid metabolites.
• Chain: C
• Resolution: 2.9 Å

Enzymatic activity

• Enzyme Commision number: 1.4.1.4: glutamate dehydrogenase (NADP(+)).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NDP	C	K122 D154 I155 R193 T197 S229 G230 N231 V232 D252 S253 K279 Q284 A320 T321 S345 N346 N379	K122 D154 I155 R193 T197 S229 G230 N231 V232 D252 S253 K279 Q284 A320 T321 S345 N346 N379

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004353 glutamate dehydrogenase [NAD(P)+] activity
• GO:0004354 glutamate dehydrogenase (NADP+) activity
• GO:0016491 oxidoreductase activity
• GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

Biological Process

• GO:0006520 amino acid metabolic process
• GO:0006537 glutamate biosynthetic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:7ect, PDBe:7ect, PDBj:7ect
• PDBsum: 7ect
• PubMed: 34748226
• UniProt: T2D1F5