Structure of PDB 7eb2 Chain C

Receptor sequence

>7eb2C (length=678) Species: 9606 (Homo sapiens)

ERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIH
HDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVL
SYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQT
TEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGL
FYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEM
TEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQ
EAPLAYDAIWALALALNKTSRLEDFNYNNQTITDQIYRAMNSSSFEGVSG
HVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSP
PADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQ
NSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRNQFPFVCQARLWLLGLG
FSLGYGSMFTKIWWVHTVFTLEPWKLYATVGLLVGMDVLTLAIWQIVDPL
HRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGYKGLLLLLG
IFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAF
AFASLAIVFSSYITLVVLFVPKMRRLIT

3D structure

• PDB: 7eb2 Structural basis of GABA B receptor-G i protein coupling.
• Chain: C
• Resolution: 3.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	2C0	C	W182 C246 S247 G268 H287 F366 Y367 W395 E466	W17 C81 S82 G103 H122 F201 Y202 W230 E301	BindingDB: EC50=1000nM,Ki=6000nM
BS02	FN0	C	Y789 K792 M807	Y605 K608 M623	BindingDB: EC50=1900nM

Gene Ontology

Molecular Function

• GO:0004930 G protein-coupled receptor activity
• GO:0004965 G protein-coupled GABA receptor activity

Biological Process

• GO:0007186 G protein-coupled receptor signaling pathway

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:7eb2, PDBe:7eb2, PDBj:7eb2
• PDBsum: 7eb2
• PubMed: 33911284
• UniProt: Q9UBS5|GABR1_HUMAN Gamma-aminobutyric acid type B receptor subunit 1 (Gene Name=GABBR1)