Structure of PDB 7dxe Chain C

Receptor sequence
>7dxeC (length=685) Species: 9606 (Homo sapiens) [Search protein sequence]
TSLTAEEERFLDAAEYGNIPVVRKMLEESKTLNVNCVDYMGQNALQLAVG
NEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILNHPGFAASKRL
TLSPCEQELQDDDFYAYDEDGTRFSPDITPIILAAHCQKYEVVHMLLMKG
ARIERPHDYFCKCGDCMEKQRHDSFSHSRSRINAYKGLASPAYLSLSSED
PVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEV
EAILNGDSLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIA
IKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFL
GLLVFNASDRFEGITTLPNITVTDYPKQIFRVKTTQFTWTEMLIMVWVLG
MMWSECKELWLEGPREYILQLWNVLDFGMLSIFIAAFTARFLAFLQATKA
QQYVDSYVQESDLSEVTLPPEIQYFTYARDKWLPSDPQIISEGLYAIAVV
LSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFI
LYSYYLGAKVNAAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIG
YVLYGIYNVTMVVVLLNMLIAMINSSYDDSDVEWKFARSKLWLSYFDKTL
PPPFSLVPQPTRYQQIMKRLIKRYVLKAQVDKEND
3D structure
PDB7dxe Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.
ChainC
Resolution3.2 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y01 C M574 F577 M539 F542
BS02 98R C F606 F610 W611 F571 F575 W576
BS03 98R C N633 Y636 I641 N598 Y601 I606
BS04 Y01 C K337 I382 I541 K302 I347 I506
BS05 ZN C H178 C182 C184 C187 H157 C161 C163 C166
BS06 Y01 C A470 L477 A435 L442
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005227 calcium-activated cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0015279 store-operated calcium channel activity
GO:0046872 metal ion binding
GO:0070679 inositol 1,4,5 trisphosphate binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006816 calcium ion transport
GO:0007338 single fertilization
GO:0007602 phototransduction
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0033198 response to ATP
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051592 response to calcium ion
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:1903244 positive regulation of cardiac muscle hypertrophy in response to stress
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034703 cation channel complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7dxe, PDBe:7dxe, PDBj:7dxe
PDBsum7dxe
PubMed35051376
UniProtQ13507|TRPC3_HUMAN Short transient receptor potential channel 3 (Gene Name=TRPC3)

[Back to BioLiP]