Structure of PDB 7d4q Chain C

Receptor sequence
>7d4qC (length=668) Species: 9606 (Homo sapiens) [Search protein sequence]
RIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCM
DPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLL
SYTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVEC
VSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELS
KVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDLAKLKVA
IKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPM
LSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQDLHVQGP
PPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLA
TISLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFT
ANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAID
EPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTE
FVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWM
SYFDEGGTLPPPFNIISLIQNQHYQEVIRNLVKRYVAAMIRNSKTTEENF
KELKQDISSFRYEVLDLL
3D structure
PDB7d4q Structural basis for human TRPC5 channel inhibition by two distinct inhibitors.
ChainC
Resolution2.74 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y01 C F364 F497 A499 N500 F321 F449 A451 N452
BS02 ZN C H172 C176 C178 C181 H141 C145 C147 C150
BS03 CA C E418 N436 D439 E370 N388 D391
BS04 GWR C C525 F569 L572 Q573 F576 C477 F521 L524 Q525 F528 BindingDB: IC50=9.3nM
BS05 GWR C T603 G606 T555 G558 BindingDB: IC50=9.3nM
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005262 calcium channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7d4q, PDBe:7d4q, PDBj:7d4q
PDBsum7d4q
PubMed33683200
UniProtQ9UL62|TRPC5_HUMAN Short transient receptor potential channel 5 (Gene Name=TRPC5)

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