Structure of PDB 7d3e Chain C

Receptor sequence

>7d3eC (length=1380) Species: 9606 (Homo sapiens)

QNPISWEVQRFDGWYNNLMEHRWGSKGSRLQRLVPASYADGVYQPLGEPH
LPNPRDLSNTISRGPAGLASLRNRTVLGVFFGYHVLSDLVSVETPGCPAE
FLNIRIPPGDPMFDPDQRGDVVLPFQRSRWDPETGRSPSNPRDPANQVTG
WLDGSAIYGSSHSWSDALRSFSRGQLASGPDPAFPRDSQNPLLMWAAPDP
ATGQNGPRGLYAFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWE
DEELFQHARKRVIATYQNIAVYEWLPSFLQKTLPEYTGYRPFLDPSISSE
FVAASEQFLSTMVPPGVYMRNASCHFQGVINRNSSVSRALRVCNSYWSRE
HPSLQSAEDVDALLLGMASQIAEREDHVLVEDVRDFWPGPLKFSRTDHLA
SCLQRGRDLGLPSYTKARAALGLSPITRWQDINPALSRSNDTVLEATAAL
YNQDLSWLELLPGGLLESHRDPGPLFSTIVLEQFVRLRDGDRYWFENTRN
GLFSKKEIEEIRNTTLQDVLVAVINIDPSALQPNVFVWHKGDPCPQPRQL
STEGLPACAPSVVRDYFEGSGFGFGVTIGTLCCFPLVSLLSAWIVARLGM
EALEWQGHKEPCRPVLVYLQPGQIRVVDGRLTVLRTIQLQPVNFVLSRTL
LLKIPKEYDLVLLFNLEEERQALVENLRGALKESIQEWELREQELMRAAV
TREQRRHLLETFFRHLFSQVLDINQADAGTLSQKVREALTCELSRAEFAE
SLGLKPQDMFVESMFSLADGYLSFREFLDILVVFMEEKSRLMFRMYDFDG
NGLISKDEFIRMLRSFIEISNNCLSKAQLAEVVESMFWEDFHFMLRLLFT
EAHREKFQRSCLHQTVQQFKRFIENYRRHIGCVAVFYAIAGGLFLERAYY
YAFAAHHTGITDTTRVGIILSRGTAASISFMFSYILLTMCRNLITFLRET
FLNRYVPFDAAVDFHRLIASTAIVLTVLHSVGHVVNVYLFSISPLSVLSC
LFPGLFHDDGSEFPQKYYWWFFQTVPGLTGVVLLLILAIMYVFASHHFRR
RSFRGFWLTHHLYILLYVLLIIHGSFALIQLPRFHIFFLVPAIIYGGDKL
VSLSRKKVEISVVKAELLPSGVTHLRFQRPQGFEYKSGQWVRIACLALGT
TEYHPFTLTSAPHEDTLSLHIRAAGPWTTRLREIYSAPTYPKLYLDGPFG
EGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSVSCQVFCKKIYFIW
VTRTQRQFEWLADIIREVEENDHQDLVSVHIYITQLAEKFDLRTTMLYIC
ERHFQKVLNRSLFTGLRSITHFGRPPFEPFFNSLQEVHPQVRKIGVFSCG
PPGMTKNVEKACQLINRQDRTHFSHHYENF

3D structure

• PDB: 7d3e Structures of human dual oxidase 1 complex in low-calcium and high-calcium states.
• Chain: C
• Resolution: 2.8 Å

Enzymatic activity

• Enzyme Commision number: 1.11.1.-
  1.6.3.1: NAD(P)H oxidase (H2O2-forming).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MAN	C	D61 V63	D40 V42
BS02	MAN	C	H1071 H1072	H906 H907
BS03	MAN	C	Y64 E121	Y43 E100
BS04	HEM	C	F1097 M1104 R1106 H1130 R1131 A1134 M1205 Y1206 A1209 F1221 W1222 H1225 Y1228 Y1260 K1264	F932 M939 R941 H965 R966 A969 M1040 Y1041 A1044 F1056 W1057 H1060 Y1063 Y1095 K1099
BS05	HEM	C	R1087 A1090 I1093 H1144 H1148 P1191 G1195 L1198 L1199 L1202 L1235 H1238 A1242 L1243 I1244 P1247 R1248 F1249	R922 A925 I928 H979 H983 P1026 G1030 L1033 L1034 L1037 L1070 H1073 A1077 L1078 I1079 P1082 R1083 F1084
BS06	NDP	C	R1036 E1039 N1040 Y1041 G1389 I1390 G1391 T1423 R1424 T1455 R1495 G1521 P1522 G1524 N1528 N1550	R871 E874 N875 Y876 G1218 I1219 G1220 T1252 R1253 T1284 R1324 G1350 P1351 G1353 N1357 N1379
BS07	FAD	C	V1127 D1128 R1214 W1305 H1319 P1320 F1321 T1322 H1335 I1336 R1337 G1340 P1341 W1342 T1343	V962 D963 R1049 W1140 H1154 P1155 F1156 T1157 H1170 I1171 R1172 G1175 P1176 W1177 T1178

Gene Ontology

Molecular Function

• GO:0004601 peroxidase activity
• GO:0005509 calcium ion binding
• GO:0016491 oxidoreductase activity
• GO:0020037 heme binding

Biological Process

• GO:0006979 response to oxidative stress

External links

• PDB: RCSB:7d3e, PDBe:7d3e, PDBj:7d3e
• PDBsum: 7d3e
• PubMed: 33420071
• UniProt: Q9NRD9|DUOX1_HUMAN Dual oxidase 1 (Gene Name=DUOX1)