Structure of PDB 7cx0 Chain C

Receptor sequence
>7cx0C (length=588) Species: 1351 (Enterococcus faecalis) [Search protein sequence]
EKLAKGEMNLNALFIGDKAENGQLYKDLLIDLVDEHLGWRQNYMPQDMPV
ISSQERTSKSYEKTVNHMKDVLNEISSRMRTHSVPWHTAGRYWGHMNSET
LMPSLLAYNFAMLWNGNNVAYESSPATSQMEEEVGHEFAHLMSYKNGWGH
IVADGSLANLEGLWYARNIKSLPFAMKEVKPELVAGKSDWELLNMPTKEI
MDLLESAEDEIDEIKAHSARSGKHLQAIGKWLVPQTKHYSWLKAADIIGI
GLDQVIPVPVDHNYRMDINELEKIVRGLAEEQIPVLGVVGVVGSTEEGAV
DSIDKIIALRDELMKDGIYYYVHVDAAYGGYGRAIFLDEDNNFIPYEDLQ
DVHEEYGVFKEKKEHISREVYDAYKAIELAESVTIDPHKMGYIPYSAGGI
VIQDIRMRDVISYFDIPALLGAYILEGSKAGATAASVWAAHHVLPLNVAG
YGKLIGASIEGSHHFYNFLNDLTHTLTHPDFNMVDYVFKEKGNDDLVAMN
KLNHDVYDYASYVKGNIYNNEFITSHTDFAIPDYGNSPLKFVNSDEEWNR
AGKVTVLRAAVMTPYMNDKEEFDVYAPKIQAALQEKLE
3D structure
PDB7cx0 Crystal structure of a tyrosine decarboxylase from Enterococcus faecalis in complex with the cofactor PLP and inhibitor carbidopa
ChainC
Resolution2.66 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.1.-
4.1.1.25: tyrosine decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 142 C A123 E125 A120 E122
BS02 PLP C D157 G158 S159 H241 T298 D328 A330 D389 H391 D154 G155 S156 H238 T295 D325 A327 D386 H388
BS03 142 C H98 H241 H95 H238
Gene Ontology
Molecular Function
GO:0004058 aromatic-L-amino-acid decarboxylase activity
GO:0004837 tyrosine decarboxylase activity
GO:0016830 carbon-carbon lyase activity
GO:0016831 carboxy-lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0036468 L-dopa decarboxylase activity
Biological Process
GO:0019752 carboxylic acid metabolic process
GO:1903184 L-dopa metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7cx0, PDBe:7cx0, PDBj:7cx0
PDBsum7cx0
PubMed
UniProtQ838D6|TYRDC_ENTFA L-tyrosine decarboxylase (Gene Name=tdc)

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