Structure of PDB 7cnm Chain C

Receptor sequence

>7cnmC (length=440) Species: 9823 (Sus scrofa)

MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFN
TFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAA
NNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFT
SLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDC
AFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNV
DLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTG
FKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYA
KRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSV

3D structure

• PDB: 7cnm The high-resolution X-ray structure of vinca-domain inhibitors of microtubules provides a rational approach for drug design.
• Chain: C
• Resolution: 2.44 Å

Enzymatic activity

• Enzyme Commision number: 3.6.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	G70	C	L248 N329	L248 N329
BS02	GTP	C	Q11 A12 Q15 N101 S140 G143 G144 T145 G146 V177 E183 N206 Y224 N228	Q11 A12 Q15 N101 S140 G143 G144 T145 G146 V177 E183 N206 Y224 N228
BS03	CA	C	D39 T41 G44 E55	D39 T41 G44 E55

Gene Ontology

Molecular Function

• GO:0003924 GTPase activity
• GO:0005200 structural constituent of cytoskeleton
• GO:0005525 GTP binding
• GO:0016787 hydrolase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0000226 microtubule cytoskeleton organization
• GO:0000278 mitotic cell cycle
• GO:0007017 microtubule-based process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005856 cytoskeleton
• GO:0005874 microtubule
• GO:0015630 microtubule cytoskeleton

External links

• PDB: RCSB:7cnm, PDBe:7cnm, PDBj:7cnm
• PDBsum: 7cnm
• PubMed: 33220079
• UniProt: Q2XVP4|TBA1B_PIG Tubulin alpha-1B chain (Gene Name=TUBA1B)