Structure of PDB 7cgq Chain C

Receptor sequence

>7cgqC (length=306) Species: 192 (Azospirillum brasilense)

DQVSLGVVGIGKIARDQHLPAIDAEPGFKLTACASRHAEVTGVRNYRDLR
ALLAAERELDAVSLCAPPQVRYAQARAALEAGKHVMLEKPPGATLGEVAV
LEALARERGLTLFATWHSRCASAVEPAREWLATRAIRAVQVRWKADVRRW
HPGQQWIWEPGGLGVFDPGINALSIVTRILPRELVLREATLIVPSDVQTP
IAAELDCADTDGVPVRAEFDWRHGPVEQWEIAVDTADGVLAISRGGAQLS
IAGEPVELGPEREYPALYAHFHALIARGESDVDVRPLRLVADAFLFGRRV
QTDAFG

3D structure

• PDB: 7cgq Crystal structure of bacterial L-arabinose 1-dehydrogenase in complex with L-arabinose and NADP+
• Chain: C
• Resolution: 2.208 Å

Enzymatic activity

• Enzyme Commision number: 1.1.1.120: galactose 1-dehydrogenase (NADP(+)).
  1.1.1.376: L-arabinose 1-dehydrogenase [NAD(P)(+)].
  1.1.1.48: D-galactose 1-dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAP	C	S37 R38 H39 P69 V72	S35 R36 H37 P67 V70

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0016491 oxidoreductase activity
• GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
• GO:0019151 galactose 1-dehydrogenase activity
• GO:0044103 L-arabinose 1-dehydrogenase (NADP+) activity
• GO:0047910 galactose 1-dehydrogenase (NADP+) activity
• GO:0050022 L-arabinose 1-dehydrogenase (NAD+) activity
• GO:0070401 NADP+ binding
• GO:0070403 NAD+ binding

Biological Process

• GO:0019568 arabinose catabolic process
• GO:0019570 L-arabinose catabolic process to 2-oxoglutarate
• GO:0019572 L-arabinose catabolic process

External links

• PDB: RCSB:7cgq, PDBe:7cgq, PDBj:7cgq
• PDBsum: 7cgq
• UniProt: Q53TZ2|ARAA_AZOBR L-arabinose 1-dehydrogenase (NAD(P)(+)) (Gene Name=araA)