Structure of PDB 7cfs Chain C

Receptor sequence
>7cfsC (length=426) Species: 9606 (Homo sapiens) [Search protein sequence]
SLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPA
VTLCNLNEFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQ
DKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCSAEDFKVVFT
RYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDET
SFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGT
CKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTP
EQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKY
LAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQM
GLFIGASILTVLELFDYAYEVIKHKL
3D structure
PDB7cfs Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1.
ChainC
Resolution3.56 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 Y01 C F69 M439 V450 F30 M400 V411
Gene Ontology
Molecular Function
GO:0005272 sodium channel activity
GO:0015280 ligand-gated sodium channel activity
Biological Process
GO:0006814 sodium ion transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7cfs, PDBe:7cfs, PDBj:7cfs
PDBsum7cfs
PubMed32915133
UniProtP78348|ASIC1_HUMAN Acid-sensing ion channel 1 (Gene Name=ASIC1)

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