Structure of PDB 7ccy Chain C

Receptor sequence
>7ccyC (length=322) Species: 9606 (Homo sapiens) [Search protein sequence]
RVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTGDKILDTAL
SSLFTKELEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAV
VFHPKFVGKTLETLPEKSVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTR
LRKLDEQQEFSAIILATAGLQRMGWHNRVGQILHPEECMYAVGQGALGVE
VRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLEGGCSVPVAVHTAMKD
GQLYLTGGVWSLDGSDSIQETMQATIHPQLVGITARNIPRGPQLAAQNLG
ISLANLLLSKGAKNILDVARQL
3D structure
PDB7ccy Crystal structures of hydroxymethylbilane synthase complexed with a substrate analog: a single substrate-binding site for four consecutive condensation steps.
ChainC
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K98 D99 R149 R150 R167 R173 C261
Catalytic site (residue number reindexed from 1) K75 D76 R126 R127 R144 R150 C238
Enzyme Commision number 2.5.1.61: hydroxymethylbilane synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FWL C R26 S28 Q34 F77 S96 D99 G168 N169 R173 R8 S10 Q16 F54 S73 D76 G145 N146 R150
BS02 DPM C S96 K98 D99 S146 S147 R149 R150 R173 L188 A189 C261 S73 K75 D76 S123 S124 R126 R127 R150 L165 A166 C238
Gene Ontology
Molecular Function
GO:0004418 hydroxymethylbilane synthase activity
GO:0005515 protein binding
GO:0016740 transferase activity
Biological Process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0006783 heme biosynthetic process
GO:0006784 heme A biosynthetic process
GO:0006785 heme B biosynthetic process
GO:0018160 peptidyl-pyrromethane cofactor linkage
GO:0033014 tetrapyrrole biosynthetic process
GO:0048034 heme O biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ccy, PDBe:7ccy, PDBj:7ccy
PDBsum7ccy
PubMed33600566
UniProtP08397|HEM3_HUMAN Porphobilinogen deaminase (Gene Name=HMBS)

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