Structure of PDB 7bl7 Chain C

Receptor sequence
>7bl7C (length=230) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
SGYSRVLLKLGGEMFGGGQVGLDPDVVAQVARQIADVVRGGVQIAVVIGG
GNFFRGAQLQQLGMERTRSDYMGMLGTVMNSLALQDFLEKEGIVTRVQTA
ITMGQVAEPYLPLRAVRHLEKGRVVIFGAGMGLPYFSTDTTAAQRALEIG
ADVVLMAKAVDGVFAEDPRAELLTAVSHREVLDRGLRVADATAFSLCMDN
GMPILVFNLLTDGNIARAVRGEKIGTLVTT
3D structure
PDB7bl7 Structural basis for the allosteric inhibition of UMP kinase from Gram-positive bacteria, a promising antibacterial target.
ChainC
Resolution3.33 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.4.22: UMP kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UTP C L140 R141 R144 L113 R114 R117
BS02 UTP C R123 G131 E135 R141 K148 R150 R96 G104 E108 R114 K121 R123
BS03 UDP C K36 G38 G39 G77 G78 R82 G83 D97 M101 G157 M158 L160 F163 S164 T165 K9 G11 G12 G50 G51 R55 G56 D70 M74 G130 M131 L133 F136 S137 T138
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0005524 ATP binding
GO:0009041 UMP/dUMP kinase activity
GO:0016301 kinase activity
GO:0033862 UMP kinase activity
Biological Process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006225 UDP biosynthetic process
GO:0016310 phosphorylation
GO:0044210 'de novo' CTP biosynthetic process
GO:0046940 nucleoside monophosphate phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7bl7, PDBe:7bl7, PDBj:7bl7
PDBsum7bl7
PubMed35152545
UniProtP9WHK5|PYRH_MYCTU Uridylate kinase (Gene Name=pyrH)

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