Structure of PDB 7bkg Chain C

Receptor sequence
>7bkgC (length=256) Species: 9606 (Homo sapiens) [Search protein sequence]
SGFTSKDTYLSHFNPRDYLEKYYKFGSAESQILKHLLKNLFKIFCLDGVK
GDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKAAPAAF
DWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLP
PADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYM
IGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQSYSSTMANNEGLFSL
VARKLS
3D structure
PDB7bkg Novel Inhibitors of Nicotinamide- N -Methyltransferase for the Treatment of Metabolic Disorders.
ChainC
Resolution2.326 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.1: nicotinamide N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH C Y11 Y20 Y25 G63 S64 T67 Y69 D85 Y86 N90 D142 T163 L164 A169 Y9 Y18 Y23 G58 S59 T62 Y64 D80 Y81 N85 D137 T158 L159 A164 BindingDB: IC50=35300nM
BS02 U0Z C Y20 L164 Y204 S213 Y242 Y18 L159 Y199 S208 Y237
Gene Ontology
Molecular Function
GO:0008112 nicotinamide N-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0030760 pyridine N-methyltransferase activity
Biological Process
GO:0006769 nicotinamide metabolic process
GO:0009410 response to xenobiotic stimulus
GO:0031100 animal organ regeneration
GO:0032259 methylation
GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway
GO:0045722 positive regulation of gluconeogenesis
GO:0090312 positive regulation of protein deacetylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7bkg, PDBe:7bkg, PDBj:7bkg
PDBsum7bkg
PubMed33668468
UniProtP40261|NNMT_HUMAN Nicotinamide N-methyltransferase (Gene Name=NNMT)

[Back to BioLiP]