Structure of PDB 7aag Chain C

Receptor sequence
>7aagC (length=322) Species: 9606 (Homo sapiens) [Search protein sequence]
QEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKI
PVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTD
LEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVG
FKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMV
ETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIM
EEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADL
VHPDAQDILDTLEDNREWYQST
3D structure
PDB7aag hPDE4D2 structure with inhibitor NPD-617
ChainC
Resolution1.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ILE C Y406 Q407 T409 Y319 Q320 T322
BS02 ZN C H164 H200 D201 D318 H77 H113 D114 D231
BS03 QWT C H160 M273 N321 I336 M357 Q369 G371 F372 Y375 I376 H73 M186 N234 I249 M270 Q282 G284 F285 Y288 I289 BindingDB: IC50=1.2nM
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:7aag, PDBe:7aag, PDBj:7aag
PDBsum7aag
PubMed
UniProtQ08499|PDE4D_HUMAN 3',5'-cyclic-AMP phosphodiesterase 4D (Gene Name=PDE4D)

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