Structure of PDB 6z6i Chain C

Receptor sequence
>6z6iC (length=174) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
EVNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGVAG
ALNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPNVN
KGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRTNV
YLAVFDKNLYDKLVSSFLEMKSEK
3D structure
PDB6z6i Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential.
ChainC
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A1R C D226 I227 A242 N244 V253 A254 L330 S332 A333 G334 I335 F336 A358 F360 D21 I22 A37 N39 V48 A49 L125 S127 A128 G129 I130 F131 A153 F155
BS02 A1R C N321 E324 R352 T353 N116 E119 R147 T148
External links
PDB RCSB:6z6i, PDBe:6z6i, PDBj:6z6i
PDBsum6z6i
PubMed33202171
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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