Structure of PDB 6z2h Chain C

Receptor sequence

>6z2hC (length=263) Species: 9606 (Homo sapiens)

HMKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLP
KYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGD
RFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNP
DMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAF
VDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGL
YRHPWDDISYVLP

3D structure

• PDB: 6z2h Acetyl-CoA is produced by the citrate synthase homology module of ATP-citrate lyase.
• Chain: C
• Resolution: 1.8 Å

Enzymatic activity

• Enzyme Commision number: 2.3.3.8: ATP citrate synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	Q5B	C	H900 V904 G936 A938 L969 I970 M971 G972 I973 H975 R976 R986 L1021 N1024 D1026 R1065	H67 V71 G103 A105 L136 I137 M138 G139 I140 H142 R143 R153 L188 N191 D193 R232
BS02	OAA	C	H900 V904 H975 R986 R1065	H67 V71 H142 R153 R232
BS03	ACO	C	G936 A938 L969 I970 M971 G972 I973 R976 L1021 N1024	G103 A105 L136 I137 M138 G139 I140 R143 L188 N191

Gene Ontology

Molecular Function

• GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer

External links

• PDB: RCSB:6z2h, PDBe:6z2h, PDBj:6z2h
• PDBsum: 6z2h
• PubMed: 34294920
• UniProt: P53396|ACLY_HUMAN ATP-citrate synthase (Gene Name=ACLY)