Structure of PDB 6ywl Chain C

Receptor sequence
>6ywlC (length=173) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence]
GHMVNSFSGYLKLTDNVYIKNADIVEEAKKVKPTVVVNAANVYLKHGGGV
AGALNKATNNAMQVESDDYIATNGPLKVGGSCVLSGHNLAKHCLHVVGPN
VNKGEDIQLLKSAYENFNQHEVLLAPLLSAGIFGADPIHSLRVCVDTVRT
NVYLAVFDKNLYDKLVSSFLEMK
3D structure
PDB6ywl Structural Insights into Plasticity and Discovery of Remdesivir Metabolite GS-441524 Binding in SARS-CoV-2 Macrodomain.
ChainC
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 APR C D22 I23 A38 N40 G48 V49 A50 L126 S128 A129 G130 I131 F132 A154 F156 D23 I24 A39 N41 G49 V50 A51 L127 S129 A130 G131 I132 F133 A155 F157
BS02 MG C G0 H1 E120 G1 H2 E121
External links
PDB RCSB:6ywl, PDBe:6ywl, PDBj:6ywl
PDBsum6ywl
PubMed33850605
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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