Structure of PDB 6yvt Chain C

Receptor sequence
>6yvtC (length=196) Species: 9606 (Homo sapiens) [Search protein sequence]
LPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDRGDKIT
WIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNG
TGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIE
PKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKY
3D structure
PDB6yvt Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors.
ChainC
Resolution2.847 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.29: hypoxia-inducible factor-proline dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN C H313 D315 H374 H106 D108 H167
BS02 PW2 C M299 Y303 Y310 H313 I327 Y329 H374 V376 R383 M92 Y96 Y103 H106 I120 Y122 H167 V169 R176
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418 L-ascorbic acid binding

View graph for
Molecular Function
External links
PDB RCSB:6yvt, PDBe:6yvt, PDBj:6yvt
PDBsum6yvt
PubMed22639232
UniProtQ9GZT9|EGLN1_HUMAN Egl nine homolog 1 (Gene Name=EGLN1)

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