Structure of PDB 6yq1 Chain C

Receptor sequence
>6yq1C (length=264) Species: 9606 (Homo sapiens) [Search protein sequence]
TRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTS
DSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFL
QVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVK
LGDFGLSRYMKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKP
FQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTEL
KAQLSTILEEEKAQ
3D structure
PDB6yq1 Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2.
ChainC
Resolution1.784 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D546 A548 R550 N551 D564
Catalytic site (residue number reindexed from 1) D135 A137 R139 N140 D153
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P7N C R426 I428 E430 V436 A452 E500 L501 C502 G505 L553 D564 L567 S568 R15 I17 E19 V25 A41 E89 L90 C91 G94 L142 D153 L156 S157
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6yq1, PDBe:6yq1, PDBj:6yq1
PDBsum6yq1
PubMed33497606
UniProtQ05397|FAK1_HUMAN Focal adhesion kinase 1 (Gene Name=PTK2)

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