Structure of PDB 6xsw Chain C

Receptor sequence
>6xswC (length=220) Species: 9606 (Homo sapiens) [Search protein sequence]
RAACQAKRGDQRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFN
NSRCDPACSSPACLYDNFDCHAERTCNPVYEKYCADHFADGRCDQGCNTE
ECGWDGLDCASVPALLARGVLVLTVLLPPEELLRSSADFLQRLSAILRTS
LRFRLDAHGQAMVFPYHRPEVGSVVMLEIDNRLCLHCFPDAQSAADYLGA
LSAVERLDFPYPLRDVRGEP
3D structure
PDB6xsw NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells.
ChainC
Resolution2.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA C K1396 D1399 R1401 D1403 D1414 D1417 K7 D10 R12 D14 D25 D28
BS02 CA C H1479 D1482 R1484 D1486 D1497 D1500 H87 D90 R92 D94 D105 D108
BS03 CA C L1437 N1440 R1442 D1444 D1455 D1458 L48 N51 R53 D55 D66 D69
Gene Ontology
Biological Process
GO:0007219 Notch signaling pathway
GO:0007275 multicellular organism development
GO:0030154 cell differentiation
Cellular Component
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:6xsw, PDBe:6xsw, PDBj:6xsw
PDBsum6xsw
PubMed34095881
UniProtQ9UM47|NOTC3_HUMAN Neurogenic locus notch homolog protein 3 (Gene Name=NOTCH3)

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