Structure of PDB 6x6u Chain C

Receptor sequence

>6x6uC (length=623) Species: 1185654 (Pyrococcus furiosus COM1)

MYAYNGKLLDVDLTREKVKEVELSEDVLKKFYGGRGLGTYILWKELGEKW
EKVDPLGEENLLLILTGPLTGYYPGMKTSIVSKSPESNGVVGSVLSSELG
LELKAAGYDGIIIRGKAKSPVYLFIHNDTVEIRDATKYWGMGGIELYKTL
LKEVHEEIRKKEKLKGVPKEPAMIYIGKGGENKVRFAAIMTKLMHAAGYG
GYGAVMGSKNLKAVIAKGSGPLPEVYDKEKMKVLLREFWKELFSMTTFRE
WGTGAGGYSVGHDRSSEPIRNWQEEYHDNEEISVVNFENRTWIKKYWADY
GCPVNCMKISYLRYGPYKGSISDAPDYELQAYMGTNLGIFEPEKIVYLSY
LVDELGLDGINTGNILGFAAELYQRGILTKEDLGFELNWGDEKAFAKLLH
LIVEKEGIGKILAEGTYRAALKISEIKGIDVTKYAVHVKGIAVGAHGIRS
ELDYTKDISYAVSVQGGDHTSTAALPAKGYTGELVEAFYDSAVICNFVTK
PGFEKIIEFGNALSGFNITPEQWLNEIGLRIIHLQRILLLLGGPDVYWDP
RKDDDNPPRFYEPLPSGPVKGKAPNREDIKAKVKQYYEEIGYDEHGIPKE
EVLEELGIGEAKREVKRIKKRLN

3D structure

• PDB: 6x6u An unprecedented function for a tungsten-containing oxidoreductase.
• Chain: C
• Resolution: 1.944 Å

Enzymatic activity

• Enzyme Commision number: 1.2.7.5: aldehyde ferredoxin oxidoreductase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PTE	C	K77 S93 V94 L95 S96 H195 A196 G198 Y199 D326 E328 D353 D358 G359 I360 H469 T470 E486 D490 I494 C495 N496 F497	K77 S93 V94 L95 S96 H195 A196 G198 Y199 D326 E328 D353 D358 G359 I360 H469 T470 E486 D490 I494 C495 N496 F497
BS02	SF4	C	S96 D299 C302 C306 C495	S96 D299 C302 C306 C495
BS03	MG	C	M194 D323 D326	M194 D323 D326
BS04	PO4	C	R249 Y296	R249 Y296

Gene Ontology

Molecular Function

• GO:0009055 electron transfer activity
• GO:0016491 oxidoreductase activity
• GO:0016625 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor
• GO:0046872 metal ion binding
• GO:0051536 iron-sulfur cluster binding
• GO:0051539 4 iron, 4 sulfur cluster binding

External links

• PDB: RCSB:6x6u, PDBe:6x6u, PDBj:6x6u
• PDBsum: 6x6u
• PubMed: 36269456
• UniProt: I6V2C3