Structure of PDB 6x2w Chain C

Receptor sequence
>6x2wC (length=994) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
SMEGILDFSNDLDIALLDQVVSTFYQGSGVQQKQAQEILTKFQDNPDAWQ
KADQILQFSTNPQSKFIALSILDKLITRKWKLLPNDHRIGIRNFVVGMII
SMCQDDEVFKTQKNLINKSDLTLVQILKQEWPQNWPEFIPELIGSSSSSV
NVCENNMIVLKLLSEEVFDFSAEQMTQAKALHLKNSMSKEFEQIFKLCFQ
VLEQGSSSSLIVATLESLLRYLHWIPYRYIYETNILELLSTKFMTSPDTR
AITLKCLTEVSNLKIPQDNDLIKRQTVLFFQNTLQQIATSVMPVTADLKA
TYANANGNDQSFLQDLAMFLTTYLARNRALLESDESLRELLLNAHQYLIQ
LSKIEERELFKTTLDYWHNLVADLFYEPLKKHIYEEICSQLRLVIIENMV
RPTIQLYKSEREVLVYLTHLNVIDTEEIMISKLARQIDGSEWSWHNINTL
SWAIGSISGTMSEDTEKRFVVTVIKDLLGLCEQKRGKDNKAVVASDIMYV
VGQYPRFLKAHWNFLRTVILKLFKFMHETHEGVQDMACDTFIKIVQKCKY
HFVIQQPRESEPFIQTIIRDIQKTTADLQPQQVHTFYKACGIIISEERSV
AERNRLLSDLMQLPNMAWDTIVEQSTANPTLLLDSETVKIIANIIKTNVA
VCTSMGADFYPQLGHIYYNMLQLYRAVSSMISAQVAAEGLIATKTPKVRG
LRTIKKEILKLVETYISKARNLDDVVKVLVEPLLNAVLEDYMNNVPDARD
AEVLNCMTTVVEKVGHMIPQGVILILQSVFECTLDMINKDFTEYPEHRVE
FYKLLKVINEKSFAAFLELPPAAFKLFVDAICWAFKHNNRDVEVNGLQIA
LDLVKNIERMGNVPFANEFHKNYFFIFVSETFFVLTDSDHKSGFSKQALL
LMKLISLVYDNKISVPLYQEAEVPQGTSNQVYLSQYLANMLSNAFPHLTS
EQIASFLSALTKQCKDLVVFKGTLRDFLVQIKEVGGDPTDYLFA
3D structure
PDB6x2w Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation.
ChainC
Resolution3.001 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C C539 E540 K545 K548 H569 T575 K579 C481 E482 K487 K490 H511 T517 K521
Gene Ontology
Molecular Function
GO:0005049 nuclear export signal receptor activity
GO:0005515 protein binding
GO:0017070 U6 snRNA binding
GO:0030619 U1 snRNA binding
GO:0030620 U2 snRNA binding
GO:0030621 U4 snRNA binding
GO:0030623 U5 snRNA binding
GO:0031267 small GTPase binding
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0000055 ribosomal large subunit export from nucleus
GO:0000056 ribosomal small subunit export from nucleus
GO:0006406 mRNA export from nucleus
GO:0006409 tRNA export from nucleus
GO:0006611 protein export from nucleus
GO:0006886 intracellular protein transport
GO:0015031 protein transport
GO:0034501 protein localization to kinetochore
GO:0051168 nuclear export
GO:0051170 import into nucleus
GO:0071528 tRNA re-export from nucleus
Cellular Component
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005816 spindle pole body
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6x2w, PDBe:6x2w, PDBj:6x2w
PDBsum6x2w
PubMed32520643
UniProtP30822|XPO1_YEAST Exportin-1 (Gene Name=CRM1)

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