Structure of PDB 6x17 Chain C

Receptor sequence
>6x17C (length=415) Species: 53953 (Pyrococcus horikoshii) [Search protein sequence]
GLYRKYIEYPVLQKILIGLILGAIVGLILGHYGYAHAVHTYVKPFGDLFV
RLLKMLVMPIVFASLVVGAASISPARLGRVGVKIVVYYLLTSAFAVTLGI
IMARLFNPGAGIHLAVGGQQFQPHQAPPLVHILLDIVPTNPFGALANGQV
LPTIFFAIILGIAITYLMNSENEKVRKSAETLLDAINGLAEAMYKIVNGV
MQYAPIGVFALIAYVMAEQGVHVVGELAKVTAAVYVGLTLQILLVYFVLL
KIYGIDPISFIKHAKDAMLTAFVTRSSSGTLPVTMRVAKEMGISEGIYSF
TLPLGATINMDGTALYQGVCTFFIANALGSHLTVGQQLTIVLTAVLASIG
TAGVPGAGAIMLAMVLHSVGLPLTDPNVAAAYAMILGIDAILDMGRTMVN
VTGDLTGTAIVAKTE
3D structure
PDB6x17 Large domain movements through the lipid bilayer mediate substrate release and inhibition of glutamate transporters.
ChainC
Resolution3.66 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6OU C Y7 L53 K196 G200 Y6 L52 K195 G199
Gene Ontology
Molecular Function
GO:0005283 amino acid:sodium symporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015183 L-aspartate transmembrane transporter activity
GO:0015293 symporter activity
GO:0015501 glutamate:sodium symporter activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006865 amino acid transport
GO:0035725 sodium ion transmembrane transport
GO:0046942 carboxylic acid transport
GO:0070207 protein homotrimerization
GO:0070778 L-aspartate transmembrane transport
GO:0140009 L-aspartate import across plasma membrane
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:6x17, PDBe:6x17, PDBj:6x17
PDBsum6x17
PubMed33155546
UniProtO59010|GLT_PYRHO Glutamate transporter homolog (Gene Name=PH1295)

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