Structure of PDB 6whu Chain C

Receptor sequence

>6whuC (length=789) Species: 10116 (Rattus norvegicus)

KIVNIGAVLSTRKHEQMFREAVNQANKRIQLQATSVTHKPNAIQMALSVC
EDLISSQVYAILVSHTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSF
LRTVPPYSHQSSVWFEMMRVYNWNHIILLVSDDHEGRAAQKRLETLLEER
ERGPKAEKVLQFDPGTKNVTALLMEARELEARVIILSASEDDAATVYRAA
AMLDMTGSGYVWLVGEREISGNALRYAPDGIIGLQLINGKNESAHISDAV
GVVAQAVHELLEKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVT
GRVEFNEDGDRKFAQYSIMNLQNRKLVQVGIYNGTHVIPNDRKIIWPGGE
TEKPRGYQMSTRLKIVTIHQEPFVYVKPTMSDGTCKEEFTVNGDPVKKVI
CTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMQFTYEVHLVADGKFG
TQERVQNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKY
QGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFST
LSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLA
AFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTM
YRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGEL
FFRSGFGIGMRKDSPWKQQVSLSILKSHENGFMEDLDKTWVRYQECDSRS
NAPATLTCENMAGVFMLVAGGIVAGIFLIFIEIAYKRHK

3D structure

• PDB: 6whu Structural Basis of Functional Transitions in Mammalian NMDA Receptors.
• Chain: C
• Resolution: 3.93 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	QGM	C	Q426 F505 P537 T539 R544 Q707 S708 W752 D753	Q370 F449 P481 T483 R488 Q634 S635 W679 D680	BindingDB: Ki=6.3nM

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity
• GO:0015276 ligand-gated monoatomic ion channel activity
• GO:0038023 signaling receptor activity

Biological Process

• GO:0006811 monoatomic ion transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6whu, PDBe:6whu, PDBj:6whu
• PDBsum: 6whu
• PubMed: 32610085
• UniProt: P35439|NMDZ1_RAT Glutamate receptor ionotropic, NMDA 1 (Gene Name=Grin1)