Structure of PDB 6wgn Chain C

Receptor sequence
>6wgnC (length=163) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGADGVGKSALTIQLIQNHFVDEYDPSYRKQVVIDGETSLLD
ILDTAGQEEYSAMRDQYMRTGEGFLLVFAINNTKSFEDIHHYREQIKRVK
DSEDVPMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDD
AFYTLVREIRKHK
3D structure
PDB6wgn GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf.
ChainC
Resolution1.601 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C V9 G60 E62 D69 M72 D92 H95 Y96 Q99 V103 V9 G56 E58 D65 M68 D88 H91 Y92 Q95 V99
BS02 GNP C G13 G15 K16 S17 A18 N116 K117 D119 L120 S145 A146 G13 G15 K16 S17 A18 N112 K113 D115 L116 S141 A142
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:6wgn, PDBe:6wgn, PDBj:6wgn
PDBsum6wgn
PubMed33145412
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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