Structure of PDB 6w6h Chain C

Receptor sequence
>6w6hC (length=636) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
QALQKYSTDLTARAREGKLDPVIGRDNEIRRVVQVLSRRTKNNPVLIGEP
GVGKTAIVEGLAQRIVAGDVPESLRDKTIVALDLGSMVAGSKYRGEFEER
LKAVLDDIKNSAGQIITFIDELHTIVGAGATGAMDAGNMIKPMLARGELR
LVGATTLDEYRKHIEKDAALERRFQQVYVGEPSVEDTIGILRGLKDRYEV
HHGVRITDSALVAAATLSDRYITARFLPDKAIDLVDEAASRLRMEIDSRP
VEIDEVERLVRRLEIEEMALSKEEDEASAERLAKLRSELADQKEKLAELT
TRWQNEKNAIEIVRDLKEMLKEEVGPDDIADVVSAWTGIPAGRLLEGETA
KLLRMEDELGKRVIGQKAAVTAVSDAVRRSRAGVSDPNRPTGAFMFLGPT
GVGKTELAKALADFLFDDERAMVRIDMSEYGEKHTVARLIGAPPGYVGYE
AGGQLTEAVRRRPYTVVLFDEIEKAHPDVFDVLLQVLDEGRLTDGHGRTV
DFRNTILILTSNLGSGGSAEQVLAAVRATFKPEFINRLDDVLIFEGLNPE
ELVRIVDIQLAQLGKRLAQRRLQLQVSLPAKRWLAQRGFDPVYGARPLRR
LVQQAIGDQLAKMLLAGQVHDGDTVPVNVSPDADSL
3D structure
PDB6w6h Structural basis for aggregate dissolution and refolding by the Mycobacterium tuberculosis ClpB-DnaK bi-chaperone system.
ChainC
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C K250 Y251 T289 G654 Y655 V656 K92 Y93 T131 G445 Y446 V447
BS02 AGS C R332 R333 R172 R173
BS03 AGS C V572 I573 V611 G612 K613 T614 E615 R805 R808 V363 I364 V402 G403 K404 T405 E406 R596 R599
BS04 AGS C I181 G211 K212 L354 I23 G53 K54 L194
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0009408 response to heat
GO:0034605 cellular response to heat
GO:0042026 protein refolding
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6w6h, PDBe:6w6h, PDBj:6w6h
PDBsum6w6h
PubMed34038719
UniProtP9WPD1|CLPB_MYCTU Chaperone protein ClpB (Gene Name=clpB)

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