Structure of PDB 6vzu Chain C

Receptor sequence

>6vzuC (length=396) Species: 10090 (Mus musculus)

KRLVINLSNCRYDSVRRAAQQYGLREAGDNDDWTLYWTDYSVSLERVMEM
KSYQKINHFPGMSEICRKDLLARNMSRMLKLFPKDFHFFPRTWCLPADWG
DLQTYSRTRKNKTYICKPDSGCQGRGIFITRSVKEIKPGEDMICQLYISK
PFIIDGFKFDLRVYVLVTSCDPLRVFVYNEGLARFATTSYSHPNLDNLDE
ICMHLTNYSINKHSSNFVQDAFSGSKRKLSTFNSYMKTHGYDVEQIWRGI
EDVIIKTLISAHPVIKHNYHTCFPSHTLNSACFEILGFDILLDRKLKPWL
LEVNHSPSFSTDSKLDKEVKDSLLYDALVLINLGNCDKKKVLEEERQRGR
EIRLEEVKGFQAMRLQKTEEYEKKNCGGFRLIYPGLNLEKYDKFFQ

3D structure

• PDB: 6vzu Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes.
• Chain: C
• Resolution: 1.98 Å

Enzymatic activity

• Enzyme Commision number: 6.3.2.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	RZV	C	R148 K169 T170 L203 Y204 I205 S206 W356	R91 K112 T113 L146 Y147 I148 S149 W299
BS02	MG	C	E359 N361	E302 N304
BS03	MG	C	D346 E359	D289 E302
BS04	RZP	C	C179 Q180 R219 L239 R241 N264 Y265 S266 K283 E359 N361 S363 P364 S365 K377	C122 Q123 R162 L182 R184 N207 Y208 S209 K226 E302 N304 S306 P307 S308 K320
BS05	ADP	C	K125 I172 K174 C179 G181 I184 Q202 Y204 I205 K215 D217 T263 N264 L358 E359	K68 I115 K117 C122 G124 I127 Q145 Y147 I148 K158 D160 T206 N207 L301 E302

Gene Ontology

Biological Process

• GO:0036211 protein modification process

External links

• PDB: RCSB:6vzu, PDBe:6vzu, PDBj:6vzu
• PDBsum: 6vzu
• PubMed: 32747782
• UniProt: A4Q9E8|TTLL6_MOUSE Tubulin polyglutamylase TTLL6 (Gene Name=Ttll6)