Structure of PDB 6vzq Chain C

Receptor sequence

>6vzqC (length=403) Species: 10090 (Mus musculus)

KKRLVINLSNCRYDSVRRAAQQYGLREAGDNDDWTLYWTDYSVSLERVME
MKSYQKINHFPGMSEICRKDLLARNMSRMLKLFPKDFHFFPRTWCLPADW
GDLQTYSRTRKNKTYICKPDSGARGRGIFITRSVKEIKPGEDMICQLYIS
KPFIIDGFKFDLRVYVLVTSCDPLRVFVYNEGLARFATTSYSHPNLDNLD
EICMHLTNYSINKHSSNFVQDAFSGSKRKLSTFNSYMKTHGYDVEQIWRG
IEDVIIKTLISAHPVIKHNYHTCFPHTLNSACFEILGFDILLDRKLKPWL
LEVNISPSFSTDSKLDKEVKDSLLYDALVLINLGNCDKKKVLEEERQRGR
FLQQCPNREIRLEEVKGFQAMRLQKTEEYEKKNCGGFRLIYPGLNLEKYD
KFF

3D structure

• PDB: 6vzq Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes.
• Chain: C
• Resolution: 3.08 Å

Enzymatic activity

• Enzyme Commision number: 6.3.2.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ADP	C	K125 I172 K174 A179 R180 G181 Q202 Y204 I205 K215 D217 T263 N264 L358 E359	K69 I116 K118 A123 R124 G125 Q146 Y148 I149 K159 D161 T207 N208 L301 E302
BS02	RZP	C	A179 R180 R219 R241 N264 Y265 S266 K283 N361 I362 S363 P364 S365 K377	A123 R124 R163 R185 N208 Y209 S210 K227 N304 I305 S306 P307 S308 K320
BS03	MG	C	A179 E359	A123 E302

Gene Ontology

Biological Process

• GO:0036211 protein modification process

External links

• PDB: RCSB:6vzq, PDBe:6vzq, PDBj:6vzq
• PDBsum: 6vzq
• PubMed: 32747782
• UniProt: A4Q9E8|TTLL6_MOUSE Tubulin polyglutamylase TTLL6 (Gene Name=Ttll6)